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Trials recruiting now, the landmark trials, the key papers and what they mean, the latest literature, and the milestones year by year.
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It is the allele-level prognosis behind reading the KRAS variant rather than 'KRAS mutant', and it shows the older EUS assay over-called wild-type (33%).
Consolidation chemoradiotherapy is optional in locally advanced pancreatic cancer, used for local control rather than survival; erlotinib has no role.
Systemic chemotherapy is the backbone for locally advanced pancreatic cancer; consolidation chemoradiotherapy is an option to control local symptoms or as a bridge to surgery rather than a survival treatment.
With FOLFIRINOX this trial defined the two chemotherapy standards for metastatic pancreatic cancer that still apply, and the gemcitabine and nab-paclitaxel backbone is the comparator in most current first-line pancreatic trials.
It carried Iacobuzio-Donahue's autopsy finding into the clinic on a routine stain of the diagnostic sample, the basis for the still-unvalidated idea of choosing radiotherapy by SMAD4 status.
FOLFIRINOX and, soon after, gemcitabine plus nab-paclitaxel ended the era of single-agent gemcitabine for metastatic pancreatic cancer. The regimen's modified form later improved survival after surgery in PRODIGE 24, and its toxicity is why fitness, not just stage, decides which treatment a patient is offered.
The first of the negative checkpoint trials that define pancreatic cancer as immunologically cold, with a single anecdote that kept the field going.
SMAD4 status is the clearest published molecular marker of how pancreatic cancer will behave: intact argues for local control, lost argues for systemic therapy.
Query for this cancer: (TITLE:"Locally advanced unresectable pancreatic ductal adenocarcinoma" OR ABSTRACT:"Locally advanced unresectable pancreatic ductal adenocarcinoma" OR TITLE:"Locally advanced pancreatic cancer" OR ABSTRACT:"Locally advanced pancreatic cancer" OR TITLE:"LAPC" OR ABSTRACT:"LAPC" OR TITLE:"Unresectable non-metastatic pancreatic cancer" OR ABSTRACT:"Unresectable non-metastatic pancreatic cancer" OR TITLE:"Stage III pancreatic adenocarcinoma" OR ABSTRACT:"Stage III pancreatic adenocarcinoma") AND (treatment OR therapy OR trial OR survival OR diagnosis). Results are unfiltered search hits about Locally advanced unresectable pancreatic ductal adenocarcinoma, not a curated reading list.