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Trials recruiting now, the landmark trials, the key papers and what they mean, the latest literature, and the milestones year by year.
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Query for this cancer: (TITLE:"Metastatic cancer" OR ABSTRACT:"Metastatic cancer" OR TITLE:"cancer that has spread" OR ABSTRACT:"cancer that has spread" OR TITLE:"Metastatic Cancer" OR ABSTRACT:"Metastatic Cancer" OR TITLE:"Secondary cancer" OR ABSTRACT:"Secondary cancer" OR TITLE:"Advanced cancer" OR ABSTRACT:"Advanced cancer" OR TITLE:"Stage 4 cancer" OR ABSTRACT:"Stage 4 cancer") AND (treatment OR therapy OR trial OR survival OR diagnosis). Results are unfiltered search hits about Metastatic cancer (cancer that has spread), not a curated reading list.
Hellman and Weichselbaum argue that some patients have a limited metastatic state that local treatment could control, the idea SABR-COMET later tested.
Temel and colleagues randomise newly diagnosed metastatic lung cancer patients to early palliative care with standard oncology: better quality of life, less depression and no loss of survival.
Pembrolizumab is approved for any solid tumour with mismatch-repair deficiency or microsatellite instability, the first cancer drug approved by biomarker rather than organ.
Five-year survival more than doubles with stereotactic radiotherapy to all metastases in the randomised phase 2 trial.
Stephen Paget proposed that cancers spread to organs whose environment suits them, the founding idea of metastasis research.
Bisphosphonates, then denosumab, cut fractures and other skeletal events from bone metastases.
Randomised phase 2 trial in which stereotactic radiotherapy to all sites of oligometastatic disease was associated with longer survival, launching phase 3 trials of the approach.