Primary CNS lymphoma

What changed: Primary CNS lymphoma

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Every dated change on the records linked to Primary CNS lymphoma, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

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September 2026 · 1

2026-09-08This recordPrimary CNS lymphoma
Facts on this page last checked
When this page itself was last checked or edited.

2022 · 1

2022MilestoneAutologous stem cell transplant (high-dose therapy)
IELSG32 7-year update confirms cures
A milestone in how this cancer is treated.

2017 · 2

2016 · 1

2016MilestoneRituximab
IELSG32: MATRix induction
Adding rituximab and thiotepa to methotrexate-cytarabine improves response and survival.

2010 · 1

2010MilestonePrimary CNS lymphoma
G-PCNSL-SG-1: omitting WBRT does not shorten survival
Sets the stage for radiation-free strategies.

1992 · 1

1992MilestoneMethotrexate
Methotrexate before radiotherapy doubles survival (DeAngelis)
A milestone in how this cancer is treated.

1980 · 1

1980MilestoneMethotrexate
High-dose methotrexate shown active in PCNSL
A milestone in how this cancer is treated.