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Every dated change on the records linked to Primary effusion lymphoma, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.
The effusion is drained and sent, fresh, for cytology, flow cytometry and immunohistochemistry. The diagnosis requires the Kaposi sarcoma herpesvirus latency-associated nuclear antigen in the tumour nuclei. A cavity lymphoma without the virus is a different disease, recognised separately in 2022, that arises in fluid overload from heart failure, kidney failure or cirrhosis and behaves better. HIV testing is part of the work-up in every case.
WHO-HAEM5 made fluid overload-associated large B-cell lymphoma a separate entity: the same presentation in an older person with heart, kidney or liver failure, without the virus, with a mature B-cell rather than plasmablastic phenotype, and with a better outlook.