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Numiera Therapeutics is a Colorado company repurposing etomoxir, an older heart-failure drug, to cut off the fat-burning energy supply that glioblastoma cells rely on. It holds an FDA orphan designation for malignant glioma.
Numiera Therapeutics develops small molecules aimed at cancer cell metabolism, with glioblastoma as its primary indication. Its lead asset is etomoxir, an inhibitor of carnitine palmitoyltransferase 1 (CPT1) first tested in congestive heart failure, which the company is repurposing to block fatty acid oxidation in glioma cells. The FDA designated etomoxir an orphan drug for the treatment of malignant glioma on 12 November 2024, with Numiera as sponsor. In fiscal year 2026 NCI awarded it USD 1,204,195 under SBIR award 1R44CA310352-01 for etomoxir in recurrent glioblastoma; the company announced the award in September 2026 as funding for its clinical trials.
Investors not recorded; see the round sources.
| Round | Year | Amount | Source |
|---|---|---|---|
| Grant · NCI SBIR award (R44) 1R44CA310352-01: Targeting Fatty Acid Oxidation with Etomoxir for the Treatment of Recurrent Glioblastoma | 2026 | $1M | reporter.nih.gov |
Amounts only where the cited source states them. Rounds without a public source are not listed.
Etomoxir is an older drug, first tested for heart failure, that Numiera Therapeutics is developing to starve glioblastoma cells of the fats they burn for energy. It has an FDA orphan designation for malignant glioma.
Shares Metabolic therapy: starving the tumour of a nutrient, Glioma & glioblastoma.
Shares Metabolic therapy: starving the tumour of a nutrient, Glioma & glioblastoma.
Shares Metabolic therapy: starving the tumour of a nutrient, Glioma & glioblastoma.
Shares Metabolic therapy: starving the tumour of a nutrient, Glioma & glioblastoma.
Shares Metabolic therapy: starving the tumour of a nutrient, Glioma & glioblastoma.
Shares Metabolic therapy: starving the tumour of a nutrient, Glioma & glioblastoma.
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