TaiRx
TaiRx is a Taiwan-based biotechnology company that leads 3 cancer trials in OnCo, testing the oral anti-cancer agent CVM-1118 (foslinanib) in hepatocellular carcinoma, neuroendocrine tumours, pancreatic ductal adenocarcinoma and advanced solid tumours.
Overview
TaiRx is a Taipei-based new drug development company. Its lead candidate CVM-1118 (foslinanib) is an oral anti-cancer agent in phase 2 for neuroendocrine tumours and hepatocellular carcinoma, and it also markets Zelnite, an injectable selenium product approved in Taiwan. On ClinicalTrials.gov it is the lead sponsor of 3 trials recorded in OnCo: NCT07521852 (phase 2, A Phase IIa, Single-arm, Open-label Clinical Study to Evaluate the Efficacy, Safety and...), NCT05257590 (phase 2, CVM-1118 in Combination With Nivolumab for Unresectable Advanced Hepatocellular Carcinoma) and NCT03600233 (phase 2, Study of CVM-1118 for Patients With Advanced Neuroendocrine Tumors). Sponsor and trial facts are from the ClinicalTrials.gov registry; company facts are from the official website.
Scorecard
All companies- approved products +12
- targets +2
- modalities +2
- regions +6
- 24-month regulatory events +4
- registry trials +30
Sintilimab is Innovent's PD-1 antibody, approved in China since 2018 for Hodgkin lymphoma and then, on the ORIENT trials, for first-line lung, liver, oesophageal and stomach cancer. In 2022 the FDA rejected its lung cancer application because a China-only trial against chemotherapy did not fit US practice, defining the agency's stance on single-country data.
Nivolumab was the second PD-1 blocker and is often combined with ipilimumab. Long-term data show about half of advanced melanoma patients alive at 10 years on the combination.
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