ADAMTS9
ADAMTS9 (A disintegrin and metalloproteinase with thrombospondin motifs 9) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). In addition, catalyses the shedding of the endopeptidase MMP14 (at the '314-Tyr-|-Gly-315' site), releasing the catalytic domain from the cell surface thereby preventing the downstream pro-MMP2 activation. Is involved in extracellular matrix proteolysis and in ciliary vesicle growth during ciliogenesis in metalloendopeptidase activity dependent manner. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. Location: Secreted, extracellular space, extracellular matrix; Endoplasmic reticulum; Cell projection, cilium; Recycling endosome (UniProt). Locus 3p14.1 (HGNC).
- Multiple myeloma: IntOGen driver in 1 cohort (PCM)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"ADAMTS9" OR ABSTRACT:"ADAMTS9" OR TITLE:"ADAM metallopeptidase with thrombospondin type 1 motif 9" OR ABSTRACT:"ADAM metallopeptidase with thrombospondin type 1 motif 9" OR TITLE:"A disintegrin and metalloproteinase with thrombospondin motifs 9" OR ABSTRACT:"A disintegrin and metalloproteinase with thrombospondin motifs 9" OR TITLE:"KIAA1312" OR ABSTRACT:"KIAA1312") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ADAMTS9, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/adamts9.json. Licence CC BY-NC 4.0.