ANK1 (Ankyrin-1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Angiosarcoma and 2 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. Location: Cytoplasm, cytoskeleton; Membrane; Cytoplasm, myofibril, sarcomere, M line; Sarcoplasmic reticulum (UniProt). Locus 8p11.21 (HGNC).
- Colorectal cancer: IntOGen driver in 2 cohorts (COAD, COADREAD)
- Prostate cancer: IntOGen driver in 2 cohorts (PRAD)
- Angiosarcoma: IntOGen driver in 1 cohort (ANGS)
- Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"ANK1" OR ABSTRACT:"ANK1" OR TITLE:"ankyrin 1" OR ABSTRACT:"ankyrin 1" OR TITLE:"Ankyrin-1" OR ABSTRACT:"Ankyrin-1" OR TITLE:"SPH1" OR ABSTRACT:"SPH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ANK1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ank1.json. Licence CC BY-NC 4.0.