ANK1
ANK1 (Ankyrin-1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Angiosarcoma and 2 more.
Overview
Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.
IntOGen calls it a driver in 7 cohorts (5 activating, 2 loss-of-function), covering Angiosarcoma, Cholangiocarcinoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Lung Adenocarcinoma, Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ANK1 (Ankyrin-1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Angiosarcoma and 2 more.
- 1 · What it is
ANK1 (Ankyrin-1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Angiosarcoma and 2 more.
- 2 · What goes wrong in cancer
Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane.
- 3 · How drugs use it
No product in this corpus aims at ANK1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:492 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P16157 (protein name, function text, keywords and locations (REST API)); IntOGen ANK1 (driver in 7 cohorts (Act 5, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. Location: Cytoplasm, cytoskeleton; Membrane; Cytoplasm, myofibril, sarcomere, M line; Sarcoplasmic reticulum (UniProt). Locus 8p11.21 (HGNC).
- Colorectal cancer: IntOGen driver in 2 cohorts (COAD, COADREAD)
- Prostate cancer: IntOGen driver in 2 cohorts (PRAD)
- Angiosarcoma: IntOGen driver in 1 cohort (ANGS)
- Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ANK1" OR ABSTRACT:"ANK1" OR TITLE:"ankyrin 1" OR ABSTRACT:"ankyrin 1" OR TITLE:"Ankyrin-1" OR ABSTRACT:"Ankyrin-1" OR TITLE:"SPH1" OR ABSTRACT:"SPH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ANK1, not a curated reading list.
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