IntOGen
IntOGen reads the mutations in thousands of tumour genomes and asks which genes are hit more often, or in more telling patterns, than chance allows. Those are its driver genes, and it says for each whether the mutations switch the gene on or knock it out.
Overview
IntOGen (Integrative OncoGenomics) runs several driver-discovery methods (dNdScv, OncodriveFML, OncodriveCLUSTL, HotMAPS, smRegions, CBaSE, MutPanning) over sequenced tumour cohorts from TCGA, ICGC, cBioPortal and other public sources, combines their results and publishes a Compendium of Cancer Genes: each row a gene, a cohort, the methods that called it, the share of samples mutated and a role (Act for activating, LoF for loss-of-function). The 2024-09-20 release ships under CC0 1.0 and feeds the driver roles and the cohort-driver evidence tier on OnCo's gene pages, which list the genes it calls.
Notes
top- OnCo uses only the current CC0 release; the pre-2019 archives on the download page carry a CC BY-NC 4.0 licence and are not read.
- Cancer type codes follow OncoTree-style acronyms (BRCA, LUAD, COADREAD); the cohorts table gives their names.