ACSM3
ACSM3 (Acyl-coenzyme A synthetase ACSM3, mitochondrial) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
Overview
Catalyses the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Glioblastoma Multiforme.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ACSM3 (Acyl-coenzyme A synthetase ACSM3, mitochondrial) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
- 1 · What it is
ACSM3 (Acyl-coenzyme A synthetase ACSM3, mitochondrial) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
- 2 · What goes wrong in cancer
Catalyses the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms.
- 3 · How drugs use it
No product in this corpus aims at ACSM3 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:10522 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q53FZ2 (protein name, function text, keywords and locations (REST API)); IntOGen ACSM3 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Catalyses the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms. Location: Mitochondrion; Mitochondrion matrix (UniProt). Locus 16p12.3 (HGNC).
- Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ACSM3" OR ABSTRACT:"ACSM3" OR TITLE:"acyl-CoA synthetase medium chain family member 3" OR ABSTRACT:"acyl-CoA synthetase medium chain family member 3" OR TITLE:"Acyl-coenzyme A synthetase ACSM3, mitochondrial" OR ABSTRACT:"Acyl-coenzyme A synthetase ACSM3, mitochondrial") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACSM3, not a curated reading list.