MDGA2
MDGA2 (MAM domain-containing glycosylphosphatidylinositol anchor protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Overview
May be involved in cell-cell interactions.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Melanoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MDGA2 (MAM domain-containing glycosylphosphatidylinositol anchor protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
- 1 · What it is
MDGA2 (MAM domain-containing glycosylphosphatidylinositol anchor protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
- 2 · What goes wrong in cancer
May be involved in cell-cell interactions. Location: Cell membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at MDGA2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:19835 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z553 (protein name, function text, keywords and locations (REST API)); IntOGen MDGA2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
May be involved in cell-cell interactions. Location: Cell membrane (UniProt). Locus 14q21.3 (HGNC).
- Melanoma: IntOGen driver in 1 cohort (MEL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MDGA2" OR ABSTRACT:"MDGA2" OR TITLE:"MAM domain containing glycosylphosphatidylinositol anchor 2" OR ABSTRACT:"MAM domain containing glycosylphosphatidylinositol anchor 2" OR TITLE:"MAM domain-containing glycosylphosphatidylinositol anchor protein 2" OR ABSTRACT:"MAM domain-containing glycosylphosphatidylinositol anchor protein 2" OR TITLE:"MAMDC1" OR ABSTRACT:"MAMDC1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MDGA2, not a curated reading list.