TBL1XR1
TBL1XR1 (F-box-like/WD repeat-containing protein TBL1XR1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.
Overview
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.96, animal model 0.28, genetic association 0.34, somatic mutation 0.83). IntOGen calls it a driver in 9 cohorts (8 activating, 1 loss-of-function), covering Acute Lymphoblastic Leukaemia, Burkitt Lymphoma, Invasive Breast Carcinoma, Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Non-Hodgkin Lymphoma and others.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TBL1XR1 (F-box-like/WD repeat-containing protein TBL1XR1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.
- 1 · What it is
TBL1XR1 (F-box-like/WD repeat-containing protein TBL1XR1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.
- 2 · What goes wrong in cancer
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors.
- 3 · How drugs use it
No product in this corpus aims at TBL1XR1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:29529 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BZK7 (protein name, function text, keywords and locations (REST API)); CIViC gene TBL1XR1 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000177565 (association with cancer (MONDO_0004992) 0.68; per-cancer scores at or above 0.5: melanoma 0.51, diffuse large B-cell lymphoma 0.67, non-Hodgkin lymphoma 0.74, skin cancer 0.52, breast cancer 0.58, lung cancer 0.52 (GraphQL API, CC0)); IntOGen TBL1XR1 (driver in 9 cohorts (Act 8, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Location: Nucleus (UniProt). Locus 3q26.32 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.74 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 3 cohorts (MLYM, NHL)
- Leukaemia: Open Targets association 0.59 with leukaemia (MONDO_0005059)
- Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)
- Mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 8 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TBL1XR1" OR ABSTRACT:"TBL1XR1" OR TITLE:"TBL1X/Y related 1" OR ABSTRACT:"TBL1X/Y related 1" OR TITLE:"F-box-like/WD repeat-containing protein TBL1XR1" OR ABSTRACT:"F-box-like/WD repeat-containing protein TBL1XR1" OR TITLE:"IRA1" OR ABSTRACT:"IRA1" OR TITLE:"FLJ12894" OR ABSTRACT:"FLJ12894" OR TITLE:"TBLR1" OR ABSTRACT:"TBLR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TBL1XR1, not a curated reading list.
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