LEF1
LEF1 (Lymphoid enhancer-binding factor 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Hepatocellular carcinoma and 3 more.
Overview
Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signalling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.99, animal model 0.67, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Hepatocellular Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LEF1 (Lymphoid enhancer-binding factor 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Hepatocellular carcinoma and 3 more.
- 1 · What it is
LEF1 (Lymphoid enhancer-binding factor 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Hepatocellular carcinoma and 3 more.
- 2 · What goes wrong in cancer
Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signalling pathway.
- 3 · How drugs use it
No product in this corpus aims at LEF1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:6551 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UJU2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000138795 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.59, non-Hodgkin lymphoma 0.59, skin cancer 0.53, breast cancer 0.52, leukaemia 0.61 (GraphQL API, CC0)); IntOGen LEF1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signalling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. PIAG antagonises both Wnt-dependent and Wnt-independent activation by LEF1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Location: Nucleus (UniProt). Locus 4q25 (HGNC).
- Leukaemia: Open Targets association 0.61 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.59 with non-Hodgkin lymphoma (MONDO_0018908)
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Skin cancer: Open Targets association 0.53 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)
- Acute lymphoblastic leukaemia: Open Targets association 0.59 with acute lymphoblastic leukaemia (MONDO_0004967)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LEF1" OR ABSTRACT:"LEF1" OR TITLE:"lymphoid enhancer binding factor 1" OR ABSTRACT:"lymphoid enhancer binding factor 1" OR TITLE:"Lymphoid enhancer-binding factor 1" OR ABSTRACT:"Lymphoid enhancer-binding factor 1" OR TITLE:"TCF1ALPHA" OR ABSTRACT:"TCF1ALPHA" OR TITLE:"TCF10" OR ABSTRACT:"TCF10" OR TITLE:"TCF7L3" OR ABSTRACT:"TCF7L3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LEF1, not a curated reading list.
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