TAL1
TAL1 (T-cell acute lymphocytic leukaemia protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-Hodgkin lymphoma, Skin cancer and 2 more.
Overview
Implicated in the genesis of haemopoietic malignancies. It may play an important role in haemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.90, animal model 0.64, somatic mutation 0.75). IntOGen calls it a driver in 1 cohort (0 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TAL1 (T-cell acute lymphocytic leukaemia protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-Hodgkin lymphoma, Skin cancer and 2 more.
- 1 · What it is
TAL1 (T-cell acute lymphocytic leukaemia protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-Hodgkin lymphoma, Skin cancer and 2 more.
- 2 · What goes wrong in cancer
Implicated in the genesis of haemopoietic malignancies. It may play an important role in haemopoietic differentiation.
- 3 · How drugs use it
No product in this corpus aims at TAL1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:11556 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P17542 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000162367 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.52, non-Hodgkin lymphoma 0.56, skin cancer 0.52, leukaemia 0.52 (GraphQL API, CC0)); IntOGen TAL1 (driver in 1 cohort (Act 0, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Implicated in the genesis of haemopoietic malignancies. It may play an important role in haemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. Location: Nucleus (UniProt). Locus 1p33 (HGNC).
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
- Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)
- Acute lymphoblastic leukaemia: Open Targets association 0.52 with acute lymphoblastic leukaemia (MONDO_0004967)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TAL1" OR ABSTRACT:"TAL1" OR TITLE:"TAL bHLH transcription factor 1, erythroid differentiation factor" OR ABSTRACT:"TAL bHLH transcription factor 1, erythroid differentiation factor" OR TITLE:"T-cell acute lymphocytic leukemia protein 1" OR ABSTRACT:"T-cell acute lymphocytic leukemia protein 1" OR TITLE:"bHLHa17" OR ABSTRACT:"bHLHa17" OR TITLE:"TCL5" OR ABSTRACT:"TCL5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TAL1, not a curated reading list.
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