ZMYM2
ZMYM2 (Zinc finger MYM-type protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Prostate cancer, Non-Hodgkin lymphoma and 1 more.
Overview
Involved in the negative regulation of transcription.
Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes affected pathway 0.97, literature 0.65, genetic association 0.28, somatic mutation 0.43, animal model 0.41). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZMYM2 (Zinc finger MYM-type protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Prostate cancer, Non-Hodgkin lymphoma and 1 more.
- 1 · What it is
ZMYM2 (Zinc finger MYM-type protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Prostate cancer, Non-Hodgkin lymphoma and 1 more.
- 2 · What goes wrong in cancer
Involved in the negative regulation of transcription. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ZMYM2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:12989 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UBW7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000121741 (association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.53, non-Hodgkin lymphoma 0.53, leukaemia 0.61 (GraphQL API, CC0)); IntOGen ZMYM2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Involved in the negative regulation of transcription. Location: Nucleus (UniProt). Locus 13q12.11 (HGNC).
- Leukaemia: Open Targets association 0.61 with leukaemia (MONDO_0005059)
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
- Non-Hodgkin lymphoma: Open Targets association 0.53 with non-Hodgkin lymphoma (MONDO_0018908)
- Acute lymphoblastic leukaemia: Open Targets association 0.53 with acute lymphoblastic leukaemia (MONDO_0004967)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZMYM2" OR ABSTRACT:"ZMYM2" OR TITLE:"zinc finger MYM-type containing 2" OR ABSTRACT:"zinc finger MYM-type containing 2" OR TITLE:"Zinc finger MYM-type protein 2" OR ABSTRACT:"Zinc finger MYM-type protein 2" OR TITLE:"ZNF198" OR ABSTRACT:"ZNF198") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZMYM2, not a curated reading list.
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