BAK1
BAK1 (Bcl-2 homologous antagonist/killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
Overview
Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilisation by oligomerising to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
Open Targets scores its association with cancer at 0.48 (direct and indirect evidence; datatypes literature 0.97, animal model 0.43, genetic association 0.59).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BAK1 (Bcl-2 homologous antagonist/killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
- 1 · What it is
BAK1 (Bcl-2 homologous antagonist/killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
- 2 · What goes wrong in cancer
Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilisation by oligomerising to form pores within the MOM.
- 3 · How drugs use it
No product in this corpus aims at BAK1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:949 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16611 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000030110 (association with cancer (MONDO_0004992) 0.48; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.51, non-Hodgkin lymphoma 0.51, leukaemia 0.51 (GraphQL API, CC0))
Biology
Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilisation by oligomerising to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. Location: Mitochondrion outer membrane (UniProt). Locus 6p21.31 (HGNC).
- Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908)
- Acute lymphoblastic leukaemia: Open Targets association 0.51 with acute lymphoblastic leukaemia (MONDO_0004967)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"BAK1" OR ABSTRACT:"BAK1" OR TITLE:"BCL2 antagonist/killer 1" OR ABSTRACT:"BCL2 antagonist/killer 1" OR TITLE:"Bcl-2 homologous antagonist/killer" OR ABSTRACT:"Bcl-2 homologous antagonist/killer" OR TITLE:"BCL2L7" OR ABSTRACT:"BCL2L7" OR TITLE:"CDN1" OR ABSTRACT:"CDN1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BAK1, not a curated reading list.
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