PPAT
PPAT (Amidophosphoribosyltransferase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
Overview
Catalyses the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.89, animal model 0.56, genetic association 0.60, clinical 0.66).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PPAT (Amidophosphoribosyltransferase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
- 1 · What it is
PPAT (Amidophosphoribosyltransferase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
- 2 · What goes wrong in cancer
Catalyses the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. Locus 4q12 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at PPAT yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:9238 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q06203 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000128059 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.59, non-Hodgkin lymphoma 0.59, leukaemia 0.60 (GraphQL API, CC0))
Biology
Catalyses the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. Locus 4q12 (HGNC).
- Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.59 with non-Hodgkin lymphoma (MONDO_0018908)
- Acute lymphoblastic leukaemia: Open Targets association 0.59 with acute lymphoblastic leukaemia (MONDO_0004967)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.98. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PPAT" OR ABSTRACT:"PPAT" OR TITLE:"phosphoribosyl pyrophosphate amidotransferase" OR ABSTRACT:"phosphoribosyl pyrophosphate amidotransferase" OR TITLE:"Amidophosphoribosyltransferase" OR ABSTRACT:"Amidophosphoribosyltransferase") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPAT, not a curated reading list.
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