MLLT10
MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Ovarian cancer, Leukaemia and 2 more.
Overview
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.87, animal model 0.47, genetic association 0.69, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Ovarian cancer, Leukaemia and 2 more.
- 1 · What it is
MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Ovarian cancer, Leukaemia and 2 more.
- 2 · What goes wrong in cancer
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity.
- 3 · How drugs use it
No product in this corpus aims at MLLT10 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:16063 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P55197 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000078403 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: ovarian cancer 0.57, acute lymphoblastic leukaemia 0.51, non-Hodgkin lymphoma 0.53, breast cancer 0.64, leukaemia 0.57 (GraphQL API, CC0))
Biology
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation. Location: Nucleus (UniProt). Locus 10p12.31 (HGNC).
- Breast cancer: Open Targets association 0.64 with breast cancer (MONDO_0007254)
- Ovarian cancer: Open Targets association 0.57 with ovarian cancer (MONDO_0008170)
- Leukaemia: Open Targets association 0.57 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.53 with non-Hodgkin lymphoma (MONDO_0018908)
- Acute lymphoblastic leukaemia: Open Targets association 0.51 with acute lymphoblastic leukaemia (MONDO_0004967)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MLLT10" OR ABSTRACT:"MLLT10" OR TITLE:"MLLT10 histone lysine methyltransferase DOT1L cofactor" OR ABSTRACT:"MLLT10 histone lysine methyltransferase DOT1L cofactor" OR TITLE:"AF10" OR ABSTRACT:"AF10") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MLLT10, not a curated reading list.
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