CEP43
CEP43 (Centrosomal protein 43) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
Overview
Required for anchoring microtubules to the centrosomes. Required for ciliation.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes affected pathway 0.95, literature 0.23, genetic association 0.52, somatic mutation 0.49, animal model 0.40).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CEP43 (Centrosomal protein 43) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
- 1 · What it is
CEP43 (Centrosomal protein 43) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
- 2 · What goes wrong in cancer
Required for anchoring microtubules to the centrosomes. Required for ciliation.
- 3 · How drugs use it
No product in this corpus aims at CEP43 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:17012 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95684 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000213066 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.53, non-Hodgkin lymphoma 0.53, leukaemia 0.62 (GraphQL API, CC0))
Biology
Required for anchoring microtubules to the centrosomes. Required for ciliation. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, cilium basal body (UniProt). Locus 6q27 (HGNC).
- Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.53 with non-Hodgkin lymphoma (MONDO_0018908)
- Acute lymphoblastic leukaemia: Open Targets association 0.53 with acute lymphoblastic leukaemia (MONDO_0004967)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CEP43" OR ABSTRACT:"CEP43" OR TITLE:"centrosomal protein 43" OR ABSTRACT:"centrosomal protein 43" OR TITLE:"Centrosomal protein 43" OR ABSTRACT:"Centrosomal protein 43" OR TITLE:"FGFR1OP" OR ABSTRACT:"FGFR1OP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CEP43, not a curated reading list.
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