GNB1
GNB1 (Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
Overview
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signalling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GNB1 (Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
- 1 · What it is
GNB1 (Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
- 2 · What goes wrong in cancer
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signalling systems.
- 3 · How drugs use it
No product in this corpus aims at GNB1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:4396 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62873 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000078369 (per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.55, non-Hodgkin lymphoma 0.55, leukaemia 0.55 (GraphQL API, CC0))
Biology
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signalling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Locus 1p36.33 (HGNC).
- Leukaemia: Open Targets association 0.55 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.55 with non-Hodgkin lymphoma (MONDO_0018908)
- Acute lymphoblastic leukaemia: Open Targets association 0.55 with acute lymphoblastic leukaemia (MONDO_0004967)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"GNB1" OR ABSTRACT:"GNB1" OR TITLE:"G protein subunit beta 1" OR ABSTRACT:"G protein subunit beta 1" OR TITLE:"Guanine nucleotide-binding protein G I /G S /G T subunit beta-1" OR ABSTRACT:"Guanine nucleotide-binding protein G I /G S /G T subunit beta-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GNB1, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetARID5B
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Acute lymphoblastic leukaemia, Open Targets Platform.
- TargetBAK1
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Acute lymphoblastic leukaemia, Open Targets Platform.
- TargetCEP43
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Acute lymphoblastic leukaemia, Open Targets Platform.
- TargetPPAT
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Acute lymphoblastic leukaemia, Open Targets Platform.
- TargetSET
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Acute lymphoblastic leukaemia, Open Targets Platform.
- TargetZMYM2
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Acute lymphoblastic leukaemia, Open Targets Platform.
- TargetAFF1
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Acute lymphoblastic leukaemia, Open Targets Platform.
- TargetMLLT10
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Acute lymphoblastic leukaemia, Open Targets Platform.