RPL10
RPL10 (Large ribosomal subunit protein uL16) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Leukaemia and 1 more.
Overview
Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.00, somatic mutation 0.83, clinical 0.11). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Non-Hodgkin Lymphoma, Plasma Cell Myeloma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RPL10 (Large ribosomal subunit protein uL16) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Leukaemia and 1 more.
- 1 · What it is
RPL10 (Large ribosomal subunit protein uL16) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Leukaemia and 1 more.
- 2 · What goes wrong in cancer
Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes.
- 3 · How drugs use it
No product in this corpus aims at RPL10 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:10298 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P27635 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000147403 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.50, non-Hodgkin lymphoma 0.58, leukaemia 0.52 (GraphQL API, CC0)); IntOGen RPL10 (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Location: Cytoplasm (UniProt). Locus Xq28 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.58 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 1 cohort (NHL)
- Multiple myeloma: IntOGen driver in 1 cohort (PCM)
- Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)
- Acute lymphoblastic leukaemia: Open Targets association 0.50 with acute lymphoblastic leukaemia (MONDO_0004967)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.19; IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RPL10" OR ABSTRACT:"RPL10" OR TITLE:"ribosomal protein L10" OR ABSTRACT:"ribosomal protein L10" OR TITLE:"Large ribosomal subunit protein uL16" OR ABSTRACT:"Large ribosomal subunit protein uL16" OR TITLE:"DXS648E" OR ABSTRACT:"DXS648E" OR TITLE:"DXS648" OR ABSTRACT:"DXS648" OR TITLE:"FLJ23544" OR ABSTRACT:"FLJ23544") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPL10, not a curated reading list.
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