DNM2
DNM2 (Dynamin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma, Colorectal cancer and 3 more.
Overview
Catalyses the hydrolysis of GTP and utilises this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organisation of the actin cytoskeleton. Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis. During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerisation to form a helical polymer around the vesicle membrane and leading to vesicle scission.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.54, literature 0.93, genetic association 0.00, somatic mutation 0.98, animal model 0.58).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DNM2 (Dynamin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma, Colorectal cancer and 3 more.
- 1 · What it is
DNM2 (Dynamin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma, Colorectal cancer and 3 more.
- 2 · What goes wrong in cancer
Catalyses the hydrolysis of GTP and utilises this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organisation of the actin cytoskeleton.
- 3 · How drugs use it
No product in this corpus aims at DNM2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:2974 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P50570 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000079805 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.55, acute lymphoblastic leukaemia 0.51, non-Hodgkin lymphoma 0.56, skin cancer 0.51, breast cancer 0.51, leukaemia 0.58 (GraphQL API, CC0))
Biology
Catalyses the hydrolysis of GTP and utilises this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organisation of the actin cytoskeleton. Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis. During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerisation to form a helical polymer around the vesicle membrane and leading to vesicle scission. Plays a role in organisation of the actin cytoskeleton by mediating arrangement of stress fibres and actin bundles in podocytes. During organisation of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers. Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerisation of dynamin spiral polymers, and results in dispersion of actin bundles. Location: Cytoplasm, cytoskeleton; Cytoplasmic vesicle, clathrin-coated vesicle; Cell projection, uropodium; Endosome (UniProt). Locus 19p13.2 (HGNC).
- Leukaemia: Open Targets association 0.58 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)
- Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)
- Acute lymphoblastic leukaemia: Open Targets association 0.51 with acute lymphoblastic leukaemia (MONDO_0004967)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DNM2" OR ABSTRACT:"DNM2" OR TITLE:"dynamin 2" OR ABSTRACT:"dynamin 2" OR TITLE:"Dynamin-2" OR ABSTRACT:"Dynamin-2" OR TITLE:"DYNII" OR ABSTRACT:"DYNII" OR TITLE:"DYN2" OR ABSTRACT:"DYN2" OR TITLE:"CMTDIB" OR ABSTRACT:"CMTDIB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNM2, not a curated reading list.
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