STIL
STIL (SCL-interrupting locus protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Skin cancer and Leukaemia.
Overview
Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.90).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · STIL (SCL-interrupting locus protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Skin cancer and Leukaemia.
- 1 · What it is
STIL (SCL-interrupting locus protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Skin cancer and Leukaemia.
- 2 · What goes wrong in cancer
Immediate-early gene.
- 3 · How drugs use it
No product in this corpus aims at STIL yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10879 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15468 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000123473 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: non-Hodgkin lymphoma 0.55, skin cancer 0.52, leukaemia 0.51 (GraphQL API, CC0))
Biology
Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cell cortex (UniProt). Locus 1p33 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.55 with non-Hodgkin lymphoma (MONDO_0018908)
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
- Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"STIL" OR ABSTRACT:"STIL" OR TITLE:"STIL centriolar assembly protein" OR ABSTRACT:"STIL centriolar assembly protein" OR TITLE:"SCL-interrupting locus protein" OR ABSTRACT:"SCL-interrupting locus protein" OR TITLE:"MCPH7" OR ABSTRACT:"MCPH7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STIL, not a curated reading list.
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