DNM2 (Dynamin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma, Colorectal cancer and 3 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Catalyses the hydrolysis of GTP and utilises this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organisation of the actin cytoskeleton. Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis. During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerisation to form a helical polymer around the vesicle membrane and leading to vesicle scission. Plays a role in organisation of the actin cytoskeleton by mediating arrangement of stress fibres and actin bundles in podocytes. During organisation of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers. Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerisation of dynamin spiral polymers, and results in dispersion of actin bundles. Location: Cytoplasm, cytoskeleton; Cytoplasmic vesicle, clathrin-coated vesicle; Cell projection, uropodium; Endosome (UniProt). Locus 19p13.2 (HGNC).
- Leukaemia: Open Targets association 0.58 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)
- Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)
- Acute lymphoblastic leukaemia: Open Targets association 0.51 with acute lymphoblastic leukaemia (MONDO_0004967)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"DNM2" OR ABSTRACT:"DNM2" OR TITLE:"dynamin 2" OR ABSTRACT:"dynamin 2" OR TITLE:"Dynamin-2" OR ABSTRACT:"Dynamin-2" OR TITLE:"DYNII" OR ABSTRACT:"DYNII" OR TITLE:"DYN2" OR ABSTRACT:"DYN2" OR TITLE:"CMTDIB" OR ABSTRACT:"CMTDIB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNM2, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/dnm2.json. Licence CC BY-NC 4.0.