MAF
MAF (Transcription factor Maf) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Multiple myeloma.
Overview
Acts as a transcriptional activator or repressor. Involved in embryonic lens fibre cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fibre cell differentiation.
Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes affected pathway 0.38, literature 0.82, genetic association 0.54, somatic mutation 0.81, animal model 0.76). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Plasma Cell Myeloma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MAF (Transcription factor Maf) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Multiple myeloma.
- 1 · What it is
MAF (Transcription factor Maf) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Multiple myeloma.
- 2 · What goes wrong in cancer
Acts as a transcriptional activator or repressor. Involved in embryonic lens fibre cell development.
- 3 · How drugs use it
No product in this corpus aims at MAF yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:6776 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75444 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178573 (association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: colorectal cancer 0.59 (GraphQL API, CC0)); IntOGen MAF (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Acts as a transcriptional activator or repressor. Involved in embryonic lens fibre cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fibre cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Location: Nucleus (UniProt). Locus 16q23.2 (HGNC).
- Colorectal cancer: Open Targets association 0.59 with colorectal cancer (MONDO_0005575)
- Multiple myeloma: IntOGen driver in 1 cohort (PCM)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MAF" OR ABSTRACT:"MAF" OR TITLE:"MAF bZIP transcription factor" OR ABSTRACT:"MAF bZIP transcription factor" OR TITLE:"Transcription factor Maf" OR ABSTRACT:"Transcription factor Maf" OR TITLE:"c-MAF" OR ABSTRACT:"c-MAF") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAF, not a curated reading list.