USP8
USP8 (Ubiquitin carboxyl-terminal hydrolase 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Breast cancer and 1 more.
Overview
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.85). IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Plasma Cell Myeloma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · USP8 (Ubiquitin carboxyl-terminal hydrolase 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Breast cancer and 1 more.
- 1 · What it is
USP8 (Ubiquitin carboxyl-terminal hydrolase 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Breast cancer and 1 more.
- 2 · What goes wrong in cancer
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains.
- 3 · How drugs use it
No product in this corpus aims at USP8 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:12631 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P40818 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000138592 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: breast cancer 0.53 (GraphQL API, CC0)); IntOGen USP8 (driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Location: Cytoplasm; Nucleus; Endosome membrane; Cell membrane (UniProt). Locus 15q21.2 (HGNC).
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Multiple myeloma: IntOGen driver in 1 cohort (PCM)
- Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"USP8" OR ABSTRACT:"USP8" OR TITLE:"ubiquitin specific peptidase 8" OR ABSTRACT:"ubiquitin specific peptidase 8" OR TITLE:"Ubiquitin carboxyl-terminal hydrolase 8" OR ABSTRACT:"Ubiquitin carboxyl-terminal hydrolase 8" OR TITLE:"HumORF8" OR ABSTRACT:"HumORF8" OR TITLE:"KIAA0055" OR ABSTRACT:"KIAA0055" OR TITLE:"SPG59" OR ABSTRACT:"SPG59") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about USP8, not a curated reading list.