MSI2
MSI2 (RNA-binding protein Musashi homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer and Neuroblastoma.
Overview
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.52, somatic mutation 0.98). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Neuroblastoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MSI2 (RNA-binding protein Musashi homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer and Neuroblastoma.
- 1 · What it is
MSI2 (RNA-binding protein Musashi homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer and Neuroblastoma.
- 2 · What goes wrong in cancer
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
- 3 · How drugs use it
No product in this corpus aims at MSI2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:18585 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96DH6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000153944 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: skin cancer 0.50, breast cancer 0.56 (GraphQL API, CC0)); IntOGen MSI2 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Location: Cytoplasm (UniProt). Locus 17q22 (HGNC).
- Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)
- Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898)
- Neuroblastoma: IntOGen driver in 1 cohort (NBL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MSI2" OR ABSTRACT:"MSI2" OR TITLE:"musashi RNA binding protein 2" OR ABSTRACT:"musashi RNA binding protein 2" OR TITLE:"RNA-binding protein Musashi homolog 2" OR ABSTRACT:"RNA-binding protein Musashi homolog 2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MSI2, not a curated reading list.
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