PHOX2B
PHOX2B (Paired mesoderm homeobox protein 2B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Colorectal cancer, Lung cancer and 2 more.
Overview
Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.62, animal model 0.55, genetic association 0.02, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PHOX2B (Paired mesoderm homeobox protein 2B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Colorectal cancer, Lung cancer and 2 more.
- 1 · What it is
PHOX2B (Paired mesoderm homeobox protein 2B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Colorectal cancer, Lung cancer and 2 more.
- 2 · What goes wrong in cancer
Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates.
- 3 · How drugs use it
No product in this corpus aims at PHOX2B yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:9143 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99453 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000109132 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: colorectal cancer 0.53, melanoma 0.57, neuroblastoma 0.63, skin cancer 0.56, lung cancer 0.52 (GraphQL API, CC0))
Biology
Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element. Location: Nucleus (UniProt). Locus 4p13 (HGNC).
- Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)
- Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)
- Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)
- Neuroblastoma: Open Targets association 0.63 with neuroblastoma (MONDO_0005072)
- Melanoma: Open Targets association 0.57 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PHOX2B" OR ABSTRACT:"PHOX2B" OR TITLE:"paired like homeobox 2B" OR ABSTRACT:"paired like homeobox 2B" OR TITLE:"Paired mesoderm homeobox protein 2B" OR ABSTRACT:"Paired mesoderm homeobox protein 2B" OR TITLE:"NBPhox" OR ABSTRACT:"NBPhox" OR TITLE:"PMX2B" OR ABSTRACT:"PMX2B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PHOX2B, not a curated reading list.
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