MYO5A
MYO5A (Unconventional myosin-Va) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Hepatocellular carcinoma, Lung cancer and 1 more.
Overview
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyse ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport.
IntOGen calls it a driver in 4 cohorts (2 activating, 1 loss-of-function), covering Invasive Breast Carcinoma, Hepatocellular Carcinoma, Lung, Neuroblastoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MYO5A (Unconventional myosin-Va) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Hepatocellular carcinoma, Lung cancer and 1 more.
- 1 · What it is
MYO5A (Unconventional myosin-Va) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Hepatocellular carcinoma, Lung cancer and 1 more.
- 2 · What goes wrong in cancer
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyse ATP in the presence of actin, which is essential for its function as a motor protein.
- 3 · How drugs use it
No product in this corpus aims at MYO5A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:7602 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y4I1 (protein name, function text, keywords and locations (REST API)); IntOGen MYO5A (driver in 4 cohorts (Act 2, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyse ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarisation process involved in dendrite formation. Locus 15q21.2 (HGNC).
- Breast cancer: IntOGen driver in 1 cohort (BRCA)
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Lung cancer: IntOGen driver in 1 cohort (LUNG)
- Neuroblastoma: IntOGen driver in 1 cohort (NBL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MYO5A" OR ABSTRACT:"MYO5A" OR TITLE:"myosin VA" OR ABSTRACT:"myosin VA" OR TITLE:"Unconventional myosin-Va" OR ABSTRACT:"Unconventional myosin-Va" OR TITLE:"MYO5" OR ABSTRACT:"MYO5" OR TITLE:"GS1" OR ABSTRACT:"GS1" OR TITLE:"MYR12" OR ABSTRACT:"MYR12") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYO5A, not a curated reading list.
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