PRUNE2
PRUNE2 (Protein prune homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroblastoma.
Overview
May play an important role in regulating differentiation, survival and aggressiveness of the tumour cells.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Neuroblastoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PRUNE2 (Protein prune homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroblastoma.
- 1 · What it is
PRUNE2 (Protein prune homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroblastoma.
- 2 · What goes wrong in cancer
May play an important role in regulating differentiation, survival and aggressiveness of the tumour cells. Location: Cytoplasm (UniProt).
- 3 · How drugs use it
No product in this corpus aims at PRUNE2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:25209 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WUY3 (protein name, function text, keywords and locations (REST API)); IntOGen PRUNE2 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
May play an important role in regulating differentiation, survival and aggressiveness of the tumour cells. Location: Cytoplasm (UniProt). Locus 9q21.2 (HGNC).
- Neuroblastoma: IntOGen driver in 1 cohort (NBL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PRUNE2" OR ABSTRACT:"PRUNE2" OR TITLE:"prune homolog 2 with BCH domain" OR ABSTRACT:"prune homolog 2 with BCH domain" OR TITLE:"Protein prune homolog 2" OR ABSTRACT:"Protein prune homolog 2" OR TITLE:"BMCC1" OR ABSTRACT:"BMCC1" OR TITLE:"BNIPXL" OR ABSTRACT:"BNIPXL" OR TITLE:"A214N16.3" OR ABSTRACT:"A214N16.3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PRUNE2, not a curated reading list.
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