ETV4
ETV4 (ETS translocation variant 4) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Lung cancer, Pancreatic ductal adenocarcinoma and 1 more.
Overview
Transcriptional activator. Regulates the positioning of motor neurons within the lateral medial column of the spinal cord and controls the terminal arborisation of specific motor neuron axons within their target muscles. Required for the expression of CDH8 and SEMA3E in ETV4-expressing motor neurons and for the exclusion of CDH7 expression from these neurons.
CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Trametinib. Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.99, animal model 0.41, genetic association 0.23, somatic mutation 0.97). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Neuroblastoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ETV4 (ETS translocation variant 4) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Lung cancer, Pancreatic ductal adenocarcinoma and 1 more.
- 1 · What it is
ETV4 (ETS translocation variant 4) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Lung cancer, Pancreatic ductal adenocarcinoma and 1 more.
- 2 · What goes wrong in cancer
Transcriptional activator. Regulates the positioning of motor neurons within the lateral medial column of the spinal cord and controls the terminal arborisation of specific motor neuron axons within their target muscles.
- 3 · How drugs use it
No product in this corpus aims at ETV4 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:3493 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P43268 (protein name, function text, keywords and locations (REST API)); CIViC gene ETV4 (3 evidence items, 0 assertions, 1 variants; diseases: Lung Cancer, Prostate Cancer, Pancreatic Cancer (GraphQL API, CC0)); Open Targets ENSG00000175832 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: prostate cancer 0.58 (GraphQL API, CC0)); IntOGen ETV4 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Transcriptional activator. Regulates the positioning of motor neurons within the lateral medial column of the spinal cord and controls the terminal arborisation of specific motor neuron axons within their target muscles. Required for the expression of CDH8 and SEMA3E in ETV4-expressing motor neurons and for the exclusion of CDH7 expression from these neurons. May play a role in keratinocyte differentiation. Location: Nucleus (UniProt). Locus 17q21.31 (HGNC).
- Prostate cancer: Open Targets association 0.58 with prostate cancer (MONDO_0008315); CIViC evidence names this disease
- Lung cancer: CIViC evidence names this disease
- Pancreatic ductal adenocarcinoma: CIViC evidence names this disease
- Neuroblastoma: IntOGen driver in 1 cohort (NBL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ETV4" OR ABSTRACT:"ETV4" OR TITLE:"ETS variant transcription factor 4" OR ABSTRACT:"ETS variant transcription factor 4" OR TITLE:"ETS translocation variant 4" OR ABSTRACT:"ETS translocation variant 4" OR TITLE:"E1A-F" OR ABSTRACT:"E1A-F" OR TITLE:"E1AF" OR ABSTRACT:"E1AF" OR TITLE:"PEA3" OR ABSTRACT:"PEA3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ETV4, not a curated reading list.
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