BCORL1
BCORL1 (BCL-6 corepressor-like protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Pancreatic ductal adenocarcinoma, Skin cancer and 4 more.
Overview
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.81, animal model 0.40, genetic association 0.00, somatic mutation 0.90). IntOGen calls it a driver in 6 cohorts (0 activating, 6 loss-of-function), covering Acute Myeloid Leukaemia, Colorectal Adenocarcinoma, High-Grade Glioma, NOS, Neuroblastoma, Pancreatic Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BCORL1 (BCL-6 corepressor-like protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Pancreatic ductal adenocarcinoma, Skin cancer and 4 more.
- 1 · What it is
BCORL1 (BCL-6 corepressor-like protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Pancreatic ductal adenocarcinoma, Skin cancer and 4 more.
- 2 · What goes wrong in cancer
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6.
- 3 · How drugs use it
No product in this corpus aims at BCORL1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:25657 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5H9F3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000085185 (association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: colorectal cancer 0.60, melanoma 0.52, skin cancer 0.55, breast cancer 0.54 (GraphQL API, CC0)); IntOGen BCORL1 (driver in 6 cohorts (Act 0, LoF 6); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Location: Nucleus (UniProt). Locus Xq26.1 (HGNC).
- Colorectal cancer: Open Targets association 0.60 with colorectal cancer (MONDO_0005575); IntOGen driver in 1 cohort (COADREAD)
- Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
- Neuroblastoma: IntOGen driver in 2 cohorts (NBL)
- Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 6 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: High-Grade Glioma, NOS.
Latest papers
topQuery for this target: (TITLE:"BCORL1" OR ABSTRACT:"BCORL1" OR TITLE:"BCL6 corepressor like 1" OR ABSTRACT:"BCL6 corepressor like 1" OR TITLE:"BCL-6 corepressor-like protein 1" OR ABSTRACT:"BCL-6 corepressor-like protein 1" OR TITLE:"FLJ11362" OR ABSTRACT:"FLJ11362" OR TITLE:"BCoR-L1" OR ABSTRACT:"BCoR-L1" OR TITLE:"CXorf10" OR ABSTRACT:"CXorf10") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BCORL1, not a curated reading list.
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