ZNF208
ZNF208 (Zinc finger protein 208) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma.
Overview
May be involved in transcriptional regulation.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Oesophageal Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZNF208 (Zinc finger protein 208) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma.
- 1 · What it is
ZNF208 (Zinc finger protein 208) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma.
- 2 · What goes wrong in cancer
May be involved in transcriptional regulation. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ZNF208 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:12999 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43345 (protein name, function text, keywords and locations (REST API)); IntOGen ZNF208 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 19p12 (HGNC).
- Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)
- Oesophageal and junctional adenocarcinoma: IntOGen driver in 1 cohort (ESCA)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZNF208" OR ABSTRACT:"ZNF208" OR TITLE:"zinc finger protein 208" OR ABSTRACT:"zinc finger protein 208" OR TITLE:"Zinc finger protein 208" OR ABSTRACT:"Zinc finger protein 208" OR TITLE:"PMIDP" OR ABSTRACT:"PMIDP" OR TITLE:"ZNF95" OR ABSTRACT:"ZNF95") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF208, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetCANT1
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
- TargetNUMA1
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
- TargetZNF750
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
- TargetTGFBR1
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
- TargetCTNND2
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
- TargetGRM3
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
- TrialMetabolomic and BH3 Profiling of Esophageal Cancers: Identification of Novel Assessment Methods of Treatment Response for Precision Therapy
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer.
- PersonJens Höppner
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer.