ATP2B3
ATP2B3 (Plasma membrane calcium-transporting ATPase 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Lung cancer and 2 more.
Overview
ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.51, genetic association 0.00, somatic mutation 0.85). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ATP2B3 (Plasma membrane calcium-transporting ATPase 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Lung cancer and 2 more.
- 1 · What it is
ATP2B3 (Plasma membrane calcium-transporting ATPase 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Lung cancer and 2 more.
- 2 · What goes wrong in cancer
ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals.
- 3 · How drugs use it
No product in this corpus aims at ATP2B3 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:816 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16720 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000067842 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: colorectal cancer 0.51, melanoma 0.50, skin cancer 0.55, breast cancer 0.58, lung cancer 0.51 (GraphQL API, CC0)); IntOGen ATP2B3 (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established. Location: Cell membrane; Presynaptic cell membrane (UniProt). Locus Xq28 (HGNC).
- Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254); IntOGen driver in 2 cohorts (BRCA)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)
- Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)
- Melanoma: Open Targets association 0.50 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ATP2B3" OR ABSTRACT:"ATP2B3" OR TITLE:"ATPase plasma membrane Ca2+ transporting 3" OR ABSTRACT:"ATPase plasma membrane Ca2+ transporting 3" OR TITLE:"Plasma membrane calcium-transporting ATPase 3" OR ABSTRACT:"Plasma membrane calcium-transporting ATPase 3" OR TITLE:"PMCA3" OR ABSTRACT:"PMCA3" OR TITLE:"CFAP39" OR ABSTRACT:"CFAP39" OR TITLE:"SCAX1" OR ABSTRACT:"SCAX1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATP2B3, not a curated reading list.
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