ATP2B3
ATP2B3 (Plasma membrane calcium-transporting ATPase 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Lung cancer and 2 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established. Location: Cell membrane; Presynaptic cell membrane (UniProt). Locus Xq28 (HGNC).
- Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254); IntOGen driver in 2 cohorts (BRCA)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)
- Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)
- Melanoma: Open Targets association 0.50 with melanoma (MONDO_0005105)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"ATP2B3" OR ABSTRACT:"ATP2B3" OR TITLE:"ATPase plasma membrane Ca2+ transporting 3" OR ABSTRACT:"ATPase plasma membrane Ca2+ transporting 3" OR TITLE:"Plasma membrane calcium-transporting ATPase 3" OR ABSTRACT:"Plasma membrane calcium-transporting ATPase 3" OR TITLE:"PMCA3" OR ABSTRACT:"PMCA3" OR TITLE:"CFAP39" OR ABSTRACT:"CFAP39" OR TITLE:"SCAX1" OR ABSTRACT:"SCAX1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATP2B3, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/atp2b3.json. Licence CC BY-NC 4.0.