ARHGEF10L
ARHGEF10L (Rho guanine nucleotide exchange factor 10-like protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Basal cell carcinoma and Clear cell renal cell carcinoma.
Overview
Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.
IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Basal Cell Carcinoma, Renal Clear Cell Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ARHGEF10L (Rho guanine nucleotide exchange factor 10-like protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Basal cell carcinoma and Clear cell renal cell carcinoma.
- 1 · What it is
ARHGEF10L (Rho guanine nucleotide exchange factor 10-like protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Basal cell carcinoma and Clear cell renal cell carcinoma.
- 2 · What goes wrong in cancer
Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. Location: Cytoplasm (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ARHGEF10L yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:25540 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HCE6 (protein name, function text, keywords and locations (REST API)); IntOGen ARHGEF10L (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. Location: Cytoplasm (UniProt). Locus 1p36.13 (HGNC).
- Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)
- Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)
- Clear cell renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ARHGEF10L" OR ABSTRACT:"ARHGEF10L" OR TITLE:"Rho guanine nucleotide exchange factor 10 like" OR ABSTRACT:"Rho guanine nucleotide exchange factor 10 like" OR TITLE:"Rho guanine nucleotide exchange factor 10-like protein" OR ABSTRACT:"Rho guanine nucleotide exchange factor 10-like protein" OR TITLE:"FLJ10521" OR ABSTRACT:"FLJ10521" OR TITLE:"KIAA1626" OR ABSTRACT:"KIAA1626") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ARHGEF10L, not a curated reading list.
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