SALL4
SALL4 (Sal-like protein 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Colorectal cancer, Gastric & gastro-oesophageal junction cancer and 2 more.
Overview
Transcription factor with a key role in the maintenance and self-renewal of embryonic and haematopoietic stem cells.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.99, animal model 0.29, genetic association 0.41, somatic mutation 0.98). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SALL4 (Sal-like protein 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Colorectal cancer, Gastric & gastro-oesophageal junction cancer and 2 more.
- 1 · What it is
SALL4 (Sal-like protein 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Colorectal cancer, Gastric & gastro-oesophageal junction cancer and 2 more.
- 2 · What goes wrong in cancer
Transcription factor with a key role in the maintenance and self-renewal of embryonic and haematopoietic stem cells. Location: Cytoplasm; Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at SALL4 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:15924 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UJQ4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000101115 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.55, gastric cancer 0.51, melanoma 0.55, skin cancer 0.55 (GraphQL API, CC0)); IntOGen SALL4 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Transcription factor with a key role in the maintenance and self-renewal of embryonic and haematopoietic stem cells. Location: Cytoplasm; Nucleus (UniProt). Locus 20q13.2 (HGNC).
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056)
- Chronic lymphocytic leukaemia: IntOGen driver in 1 cohort (CLLSLL)
- Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SALL4" OR ABSTRACT:"SALL4" OR TITLE:"spalt like transcription factor 4" OR ABSTRACT:"spalt like transcription factor 4" OR TITLE:"Sal-like protein 4" OR ABSTRACT:"Sal-like protein 4" OR TITLE:"dJ1112F19.1" OR ABSTRACT:"dJ1112F19.1" OR TITLE:"ZNF797" OR ABSTRACT:"ZNF797") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SALL4, not a curated reading list.