NIN
NIN (Ninein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Mesothelioma, Gastric & gastro-oesophageal junction cancer and 1 more.
Overview
Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome.
IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Colorectal Adenocarcinoma, Pleural Mesothelioma, Stomach Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NIN (Ninein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Mesothelioma, Gastric & gastro-oesophageal junction cancer and 1 more.
- 1 · What it is
NIN (Ninein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Mesothelioma, Gastric & gastro-oesophageal junction cancer and 1 more.
- 2 · What goes wrong in cancer
Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor.
- 3 · How drugs use it
No product in this corpus aims at NIN yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:14906 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8N4C6 (protein name, function text, keywords and locations (REST API)); IntOGen NIN (driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Required for centriole organisation and microtubule anchoring at the mother centriole. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cell junction, desmosome; Cytoplasm (UniProt). Locus 14q22.1 (HGNC).
- Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)
- Mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)
- Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NIN" OR ABSTRACT:"NIN" OR TITLE:"ninein" OR ABSTRACT:"ninein" OR TITLE:"Ninein" OR ABSTRACT:"Ninein") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NIN, not a curated reading list.
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