PDZD2
PDZD2 (PDZ domain-containing protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
Overview
UniProt has no function text for O15018; HGNC names it "PDZ domain containing 2".
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pleural Mesothelioma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PDZD2 (PDZ domain-containing protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
- 1 · What it is
PDZD2 (PDZ domain-containing protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
- 2 · What goes wrong in cancer
UniProt has no function text for O15018; HGNC names it "PDZ domain containing 2". Location: Nucleus; Cytoplasm; Endoplasmic reticulum; Secreted (UniProt).
- 3 · How drugs use it
No product in this corpus aims at PDZD2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:18486 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15018 (protein name, function text, keywords and locations (REST API)); IntOGen PDZD2 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
UniProt has no function text for O15018; HGNC names it "PDZ domain containing 2". Location: Nucleus; Cytoplasm; Endoplasmic reticulum; Secreted (UniProt). Locus 5p13.3 (HGNC).
- Mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PDZD2" OR ABSTRACT:"PDZD2" OR TITLE:"PDZ domain containing 2" OR ABSTRACT:"PDZ domain containing 2" OR TITLE:"PDZ domain-containing protein 2" OR ABSTRACT:"PDZ domain-containing protein 2" OR TITLE:"KIAA0300" OR ABSTRACT:"KIAA0300" OR TITLE:"PDZK3" OR ABSTRACT:"PDZK3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PDZD2, not a curated reading list.
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