PI4KA
PI4KA (Phosphatidylinositol 4-kinase alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
Overview
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Pleural Mesothelioma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PI4KA (Phosphatidylinositol 4-kinase alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
- 1 · What it is
PI4KA (Phosphatidylinositol 4-kinase alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
- 2 · What goes wrong in cancer
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. Location: Cytoplasm; Cell membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at PI4KA yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:8983 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P42356 (protein name, function text, keywords and locations (REST API)); IntOGen PI4KA (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. Location: Cytoplasm; Cell membrane (UniProt). Locus 22q11.21 (HGNC).
- Mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PI4KA" OR ABSTRACT:"PI4KA" OR TITLE:"phosphatidylinositol 4-kinase alpha" OR ABSTRACT:"phosphatidylinositol 4-kinase alpha" OR TITLE:"Phosphatidylinositol 4-kinase alpha" OR ABSTRACT:"Phosphatidylinositol 4-kinase alpha" OR TITLE:"PI4K-ALPHA" OR ABSTRACT:"PI4K-ALPHA" OR TITLE:"pi4K230" OR ABSTRACT:"pi4K230" OR TITLE:"PIK4CA" OR ABSTRACT:"PIK4CA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PI4KA, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetHLA-DQA1
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetPDZD2
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetSHTN1
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetSRGAP3
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetCYP2C8
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetTAF15
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetNIN
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
- TargetTRAF7
Shares Pleural mesothelioma, Mesothelioma, IntOGen.