SRGAP3
SRGAP3 (SLIT-ROBO Rho GTPase-activating protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
Overview
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signalling in neurons.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Pleural Mesothelioma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SRGAP3 (SLIT-ROBO Rho GTPase-activating protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
- 1 · What it is
SRGAP3 (SLIT-ROBO Rho GTPase-activating protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
- 2 · What goes wrong in cancer
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signalling in neurons.
- 3 · How drugs use it
No product in this corpus aims at SRGAP3 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:19744 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43295 (protein name, function text, keywords and locations (REST API)); IntOGen SRGAP3 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signalling in neurons. Locus 3p25.3 (HGNC).
- Mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SRGAP3" OR ABSTRACT:"SRGAP3" OR TITLE:"SLIT-ROBO Rho GTPase activating protein 3" OR ABSTRACT:"SLIT-ROBO Rho GTPase activating protein 3" OR TITLE:"SLIT-ROBO Rho GTPase-activating protein 3" OR ABSTRACT:"SLIT-ROBO Rho GTPase-activating protein 3" OR TITLE:"KIAA0411" OR ABSTRACT:"KIAA0411" OR TITLE:"MEGAP" OR ABSTRACT:"MEGAP" OR TITLE:"ARHGAP14" OR ABSTRACT:"ARHGAP14") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SRGAP3, not a curated reading list.
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