CYP2C8
CYP2C8 (Cytochrome P450 2C8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Melanoma and Pleural mesothelioma.
Overview
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Primarily catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond.
IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Melanoma, Pleural Mesothelioma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CYP2C8 (Cytochrome P450 2C8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Melanoma and Pleural mesothelioma.
- 1 · What it is
CYP2C8 (Cytochrome P450 2C8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Melanoma and Pleural mesothelioma.
- 2 · What goes wrong in cancer
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins.
- 3 · How drugs use it
No product in this corpus aims at CYP2C8 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:2622 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10632 (protein name, function text, keywords and locations (REST API)); IntOGen CYP2C8 (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Primarily catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond. Catalyses the hydroxylation of carbon-hydrogen bonds. Metabolises all trans-retinoic acid toward its 4-hydroxylated form. Displays 16-alpha hydroxylase activity toward oestrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1). Location: Endoplasmic reticulum membrane; Microsome membrane (UniProt). Locus 10q23.33 (HGNC).
- Mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Melanoma: IntOGen driver in 1 cohort (MEL)
- Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CYP2C8" OR ABSTRACT:"CYP2C8" OR TITLE:"cytochrome P450 family 2 subfamily C member 8" OR ABSTRACT:"cytochrome P450 family 2 subfamily C member 8" OR TITLE:"Cytochrome P450 2C8" OR ABSTRACT:"Cytochrome P450 2C8" OR TITLE:"CPC8" OR ABSTRACT:"CPC8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CYP2C8, not a curated reading list.
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