FLG
FLG (Filaggrin) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Mesothelioma, Acute myeloid leukaemia and 2 more.
Overview
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.91, animal model 0.57, genetic association 0.76, somatic mutation 0.17). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia, Pleural Mesothelioma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FLG (Filaggrin) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Mesothelioma, Acute myeloid leukaemia and 2 more.
- 1 · What it is
FLG (Filaggrin) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Mesothelioma, Acute myeloid leukaemia and 2 more.
- 2 · What goes wrong in cancer
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Location: Cytoplasmic granule (UniProt).
- 3 · How drugs use it
No product in this corpus aims at FLG yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:3748 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P20930 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000143631 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.63 (GraphQL API, CC0)); IntOGen FLG (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Location: Cytoplasmic granule (UniProt). Locus 1q21.3 (HGNC).
- Skin cancer: Open Targets association 0.63 with skin cancer (MONDO_0002898)
- Mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)
- Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FLG" OR ABSTRACT:"FLG" OR TITLE:"filaggrin" OR ABSTRACT:"filaggrin" OR TITLE:"Filaggrin" OR ABSTRACT:"Filaggrin" OR TITLE:"FLG1" OR ABSTRACT:"FLG1" OR TITLE:"FLG-1" OR ABSTRACT:"FLG-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FLG, not a curated reading list.
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