TAL2
TAL2 (T-cell acute lymphocytic leukaemia protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
Overview
UniProt has no function text for Q16559; HGNC names it "TAL bHLH transcription factor 2".
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.09, animal model 0.50, genetic association 0.07, somatic mutation 0.80). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Glioblastoma Multiforme.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TAL2 (T-cell acute lymphocytic leukaemia protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
- 1 · What it is
TAL2 (T-cell acute lymphocytic leukaemia protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
- 2 · What goes wrong in cancer
UniProt has no function text for Q16559; HGNC names it "TAL bHLH transcription factor 2". Locus 9q31.2 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at TAL2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:11557 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16559 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000186051 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0)); IntOGen TAL2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
UniProt has no function text for Q16559; HGNC names it "TAL bHLH transcription factor 2". Locus 9q31.2 (HGNC).
- Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TAL2" OR ABSTRACT:"TAL2" OR TITLE:"TAL bHLH transcription factor 2" OR ABSTRACT:"TAL bHLH transcription factor 2" OR TITLE:"T-cell acute lymphocytic leukemia protein 2" OR ABSTRACT:"T-cell acute lymphocytic leukemia protein 2" OR TITLE:"bHLHa19" OR ABSTRACT:"bHLHa19") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TAL2, not a curated reading list.