CCDC6
CCDC6 (Coiled-coil domain-containing protein 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Thyroid cancer, Neuroendocrine tumours and 2 more.
Overview
Acts as a structural scaffold that organises free PP2Ac into a configuration that FBXO42 can recognise and ubiquitinate, leading to its proteasomal degradation. Also interacts independently with PPP4C through a mechanism distinct from FBXO42-mediated ubiquitination.
Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes clinical 0.97, literature 0.94, genetic association 0.00, somatic mutation 0.82, animal model 0.38). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Basal Cell Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CCDC6 (Coiled-coil domain-containing protein 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Thyroid cancer, Neuroendocrine tumours and 2 more.
- 1 · What it is
CCDC6 (Coiled-coil domain-containing protein 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Thyroid cancer, Neuroendocrine tumours and 2 more.
- 2 · What goes wrong in cancer
Acts as a structural scaffold that organises free PP2Ac into a configuration that FBXO42 can recognise and ubiquitinate, leading to its proteasomal degradation.
- 3 · How drugs use it
No product in this corpus aims at CCDC6 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:18782 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16204 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108091 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.72, thyroid cancer 0.70, neuroendocrine neoplasm 0.63, lung cancer 0.72 (GraphQL API, CC0)); IntOGen CCDC6 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Acts as a structural scaffold that organises free PP2Ac into a configuration that FBXO42 can recognise and ubiquitinate, leading to its proteasomal degradation. Also interacts independently with PPP4C through a mechanism distinct from FBXO42-mediated ubiquitination. Location: Cytoplasm; Cytoplasm, cytoskeleton (UniProt). Locus 10q21.2 (HGNC).
- Lung cancer: Open Targets association 0.72 with lung cancer (MONDO_0008903)
- Thyroid cancer: Open Targets association 0.70 with thyroid cancer (MONDO_0002108)
- Neuroendocrine tumours: Open Targets association 0.63 with neuroendocrine neoplasm (MONDO_0019496)
- Non-small-cell lung cancer: Open Targets association 0.72 with non-small cell lung carcinoma (MONDO_0005233)
- Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.97; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CCDC6" OR ABSTRACT:"CCDC6" OR TITLE:"coiled-coil domain containing 6" OR ABSTRACT:"coiled-coil domain containing 6" OR TITLE:"Coiled-coil domain-containing protein 6" OR ABSTRACT:"Coiled-coil domain-containing protein 6" OR TITLE:"H4" OR ABSTRACT:"H4" OR TITLE:"PTC1" OR ABSTRACT:"PTC1" OR TITLE:"TST1" OR ABSTRACT:"TST1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCDC6, not a curated reading list.
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