EML4
EML4 (Echinoderm microtubule-associated protein-like 4) is a gene. The public catalogues list it as a drug target and a fusion partner, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Thyroid cancer and Non-small-cell lung cancer.
Overview
Essential for the formation and stability of microtubules (MTs). Required for the organisation of the mitotic spindle and for the proper attachment of kinetochores to MTs. Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression.
Open Targets scores its association with cancer at 0.84 (direct and indirect evidence; datatypes clinical 0.99, affected pathway 0.94, literature 0.98, genetic association 0.41, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EML4 (Echinoderm microtubule-associated protein-like 4) is a gene. The public catalogues list it as a drug target and a fusion partner, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Thyroid cancer and Non-small-cell lung cancer.
- 1 · What it is
EML4 (Echinoderm microtubule-associated protein-like 4) is a gene. The public catalogues list it as a drug target and a fusion partner, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Thyroid cancer and Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
Essential for the formation and stability of microtubules (MTs). Required for the organisation of the mitotic spindle and for the proper attachment of kinetochores to MTs.
- 3 · How drugs use it
No product in this corpus aims at EML4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1316 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HC35 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000143924 (association with cancer (MONDO_0004992) 0.84; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.75, thyroid cancer 0.55, lung cancer 0.76 (GraphQL API, CC0))
Biology
Essential for the formation and stability of microtubules (MTs). Required for the organisation of the mitotic spindle and for the proper attachment of kinetochores to MTs. Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression. Location: Cytoplasm, cytoskeleton; Cytoplasm; Cytoplasm, cytoskeleton, spindle; Cytoplasm, cytoskeleton, microtubule organizing center (UniProt). Locus 2p21 (HGNC).
- Lung cancer: Open Targets association 0.76 with lung cancer (MONDO_0008903)
- Thyroid cancer: Open Targets association 0.55 with thyroid cancer (MONDO_0002108)
- Non-small-cell lung cancer: Open Targets association 0.75 with non-small cell lung carcinoma (MONDO_0005233)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"EML4" OR ABSTRACT:"EML4" OR TITLE:"EMAP like 4" OR ABSTRACT:"EMAP like 4" OR TITLE:"Echinoderm microtubule-associated protein-like 4" OR ABSTRACT:"Echinoderm microtubule-associated protein-like 4" OR TITLE:"ROPP120" OR ABSTRACT:"ROPP120" OR TITLE:"ELP120" OR ABSTRACT:"ELP120" OR TITLE:"C2orf2" OR ABSTRACT:"C2orf2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EML4, not a curated reading list.
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