SRGAP1
SRGAP1 (SLIT-ROBO Rho GTPase-activating protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Overview
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signalling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.83, genetic association 0.82, genetic literature 0.61).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SRGAP1 (SLIT-ROBO Rho GTPase-activating protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 1 · What it is
SRGAP1 (SLIT-ROBO Rho GTPase-activating protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 2 · What goes wrong in cancer
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signalling of Robo and Slit proteins in neuronal migration.
- 3 · How drugs use it
No product in this corpus aims at SRGAP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:17382 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z6B7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196935 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: thyroid cancer 0.69 (GraphQL API, CC0))
Biology
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signalling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. Locus 12q14.2 (HGNC).
- Thyroid cancer: Open Targets association 0.69 with thyroid cancer (MONDO_0002108)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SRGAP1" OR ABSTRACT:"SRGAP1" OR TITLE:"SLIT-ROBO Rho GTPase activating protein 1" OR ABSTRACT:"SLIT-ROBO Rho GTPase activating protein 1" OR TITLE:"SLIT-ROBO Rho GTPase-activating protein 1" OR ABSTRACT:"SLIT-ROBO Rho GTPase-activating protein 1" OR TITLE:"KIAA1304" OR ABSTRACT:"KIAA1304" OR TITLE:"ARHGAP13" OR ABSTRACT:"ARHGAP13") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SRGAP1, not a curated reading list.
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