THRA
THRA (Thyroid hormone receptor alpha) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.
Overview
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.90, animal model 0.55, genetic association 0.00, clinical 0.91).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · THRA (Thyroid hormone receptor alpha) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.
- 1 · What it is
THRA (Thyroid hormone receptor alpha) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.
- 2 · What goes wrong in cancer
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
- 3 · How drugs use it
No product in this corpus aims at THRA yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:11796 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10827 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126351 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: thyroid cancer 0.57 (GraphQL API, CC0))
Biology
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. Location: Nucleus; Cytoplasm (UniProt). Locus 17q21.1 (HGNC).
- Thyroid cancer: Open Targets association 0.57 with thyroid cancer (MONDO_0002108)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.91. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"THRA" OR ABSTRACT:"THRA" OR TITLE:"thyroid hormone receptor alpha" OR ABSTRACT:"thyroid hormone receptor alpha" OR TITLE:"Thyroid hormone receptor alpha" OR ABSTRACT:"Thyroid hormone receptor alpha" OR TITLE:"EAR-7.1/EAR-7.2" OR ABSTRACT:"EAR-7.1/EAR-7.2" OR TITLE:"THRA3" OR ABSTRACT:"THRA3" OR TITLE:"AR7" OR ABSTRACT:"AR7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about THRA, not a curated reading list.
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