FOXE1
FOXE1 (Forkhead box protein E1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Overview
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.96, animal model 0.91, genetic association 0.71, genetic literature 0.57).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FOXE1 (Forkhead box protein E1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 1 · What it is
FOXE1 (Forkhead box protein E1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
- 2 · What goes wrong in cancer
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription.
- 3 · How drugs use it
No product in this corpus aims at FOXE1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:3806 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00358 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178919 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: thyroid cancer 0.64 (GraphQL API, CC0))
Biology
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. Location: Nucleus (UniProt). Locus 9q22.33 (HGNC).
- Thyroid cancer: Open Targets association 0.64 with thyroid cancer (MONDO_0002108)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FOXE1" OR ABSTRACT:"FOXE1" OR TITLE:"forkhead box E1" OR ABSTRACT:"forkhead box E1" OR TITLE:"Forkhead box protein E1" OR ABSTRACT:"Forkhead box protein E1" OR TITLE:"TTF-2" OR ABSTRACT:"TTF-2" OR TITLE:"HFKH4" OR ABSTRACT:"HFKH4" OR TITLE:"FKHL15" OR ABSTRACT:"FKHL15") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXE1, not a curated reading list.
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